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Some individuals report feeling overstimulated with high-dose supplementation, though these reports are anecdotal and not supported by controlled studies
2025;14(21):e043373
First, diabetes blunts weight loss by roughly 6 to 7 percentage points versus non-diabetic obesity at the same dose, because long-standing high glucose dampens the metabolic cascade the drug works through. Second, the 10-to-15 mg step keeps adding weight loss in every band
Yazigi Solis, M
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